Trulicity may cause severe stomach problems.
Nausea, vomiting, and diarrhea may cause a loss of fluids (dehydration), which could cause existing kidney problems to get worse (including kidney failure). The rates of nausea, vomiting and diarrhea, while numerically higher in each of the higher dulaglutide groups compared with the 1.5 mg group were similar between the dulaglutide 3.0 mg and 4.5 mg groups in a clinical trial. *The most common adverse reactions experienced with Trulicity are nausea, diarrhea, vomiting, abdominal pain, decreased appetite, indigestion and fatigue. With the higher dose options, about 16% of people experienced nausea and about 1% of people needed to stop taking Trulicity because of it. When you increase your dose of Trulicity, you might experience nausea. Less than 2% needed to stop taking Trulicity because of nausea.
Nausea generally subsided after the first 2 weeks, but some people experienced nausea with Trulicity beyond their second week of treatment. In studies, 8% to 29% using Trulicity experienced some nausea, which typically occurred during the first 2 to 3 days after they took their first dose. Nausea happens most often when first starting Trulicity.
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